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Phentermine (ionamin,? adipex, fastin) in 60% of patients reduced the weight by more than 5%, which was confirmed in randomized, placebo-controlled studies. in the treatment of this drug is not obtained reliable data on the possibility of its beneficial effect on the severity of dyslipidemia, hyperglycemia, and other complications of obesity. Short-range forms of the phentermine is prescribed 3 times a day 30 minutes before meals. Retard forms are taking phentermine 1 time a day before Breakfast. Phentermine is a drug of Central action. For this reason, its designation may be accompanied by the same adverse events as receiving sibutramine. In addition, long-term use of phentermine may lead to development of drug dependence, the increase of pressure in the system pulmonary artery to amplify the sympathoadrenal manifestations in the "panic attacks" in patients with anxiety disorders. Phentermine (in contrast to sibutramine and orlistat) belongs to the group of potent drugs sold only by prescription, and the duration of his appointment shall not exceed 3 months.